Papers & Poster Presentations

Real Time and Accelerated Stability Studies of Testosterone Calibrators

Authors: Linda Nagore, Ravi Orugunty, Isil Dilek, and Uma Sreenivasan
Presented at American Society for Mass Spectrometry (ASMS), San Antonio, TX, June 5-9, 2016

Potency Claims - only as Accurate as your Reference Material. Challenges with unstable THC and related Cannabinoids

Authors: Mitzi Rettinger
Presented at The Emerald Conference, Las Vegas, NV, January 21-22, 2016

Impact of isomeric differences between internal standard and analyte for the LC-MS/MS quantification of 11-Nor-δ9-THC-9-carboxylic acid glucuronide

Authors: Sarah Aijaz, Alexander Wong, Isil Dilek, and Uma Sreenivasan
Presented at The American Society for Mass Spectrometry (ASMS), St. Louis, MO, May 31-June 4, 2015

Selection of Internal Standards for LC-MS/MS Applications

Authors: Uma Sreenivasan, Isil Dilek, Josh Cooper, Sarah Aijaz, Ravi Orugunty, Derrell Johnson, Heather Lima, Mitzi Rettinger
Presented at Mass Spectrometry Applications to the Clinical Lab (MSACL), San Diego, CA, March 28-April 1, 2015

Design and Synthesis of Labeled 2C-B-FLY and Bromo-DragonFLY for Internal Standards Used in Forensic/Clinical Toxicology Analysis

Authors: Heather Lima, Uma Sreenivasan, Kenan Yaser
Presented at American Chemical Society (ACS), Dallas, TX, March 16-20, 2014

Regioselective Friedel-Crafts Type Acylation of Indoles: An Improvement on the Synthesis of Cannabimimetic Indole Metabolites

Authors: Lindsey Hess, Uma Sreenivasan, Kenan Yaser
Presented at American Chemical Society (ACS), Dallas, TX, March 16-20, 2014

Synthetic and Analytical Challenges of Retigabine and N-Acetyl Retigabine

Authors: Heather Lima, Uma Sreenivasan, Isil Dilek, Josh Cooper, Brian Dockery, and Genevieve Rodgers
Presented at Society of Forensic Toxicologists (SOFT), Orlando, FL, October 28-November 1, 2013

Analytical Reference Standards: Synthesis and Characterization of Cocaine N-oxide HCl

Authors: Yunming Ying, Brian Schulmeier, Uma Sreenivasan, Isil Dilek, Genevieve Rodgers, Sandra Ybarra
Presented at Society of Forensic Toxicologists (SOFT), Orlando, FL, October 28-November 1, 2013

Synthesis of JHW-250 4-hydroxypentyl Metabolite

Authors: Martha Liu, Kenan Yaser, Dillon Edwards and Uma Sreenivasan
Presented at 43rd National Organic Symposium Jun 23-27 at University of Washington, Seattle

Variables that Impact Immunosuppressant LC-MS/MS Analysis

Authors: Josh Cooper, Beth Marek, Isil Dilek, and Uma Sreenivasan
Presented at 61st American Society for Mass Spectrometry (ASMS) Conference, Minneapolis, MN, June 2013

Accurate Reference Standards for Accurate Quantitation of Thyroid Hormones: Impact on Clinical Reference Ranges

Authors: Beth Marek, Josh Cooper, Isil Dilek, Mitzi Rettinger, Greg Kirkovits, William Chen, Yunming Ying, Uma Sreenivasan, Matthew Crawford, Brett Holmquist, Russell P Grant
Presented at Mass Spectrometry Application to the Clinical Lab (MSACL), San Diego, CA, February 2013

Tadalafil: A Case Study for the Development of Stable Solution Reference Standards for Pharmaceutical Applications

Authors: Matthew Borer, Michael Julius, David Lytle, Tamara Tarbox, Isil Dilek, Uma Sreenivasan, Mitzi Rettinger
Presented at 11th International Symposium on Pharmaceutical Reference Standards, Strasbourg, France, September 2012

Solution Reference Standards for Protein Based Pharmaceuticals

Authors: Matthew Borer, Margaret McInerney, Kimberly Dancheck, David Lytle, Tamara Tarbox, Isil Dilek, Uma Sreenivasan, Mitzi Rettinger, Kevin Gates
Presented at 11th International Symposium on Pharmaceutical Reference Standards, Strasbourg, France, September 2012

Design and Development Challenges of Natural Products Certified Reference Solutions

Authors: Tamara Tarbox, Isil Dilek, Derrell Johnson, and Mitzi Rettinger
Presented at Association of Official Analytical Chemists (AOAC), Las Vegas, NV, October 2012

Challenges in the Development of Certified Vitamin Reference Solutions

Authors: Beth Marek, Derrell Johnson, Isil Dilek, Mitzi Rettinger
Presented at Association of Official Analytical Chemists (AOAC), Las Vegas, NV, October 2012

Accelerated Stability Studies by High Performance Liquid Chromatography

Authors: Greg Serna, Tamara Tarbox, Isil Dilek
Presented at Cerilliant - 2012 Sigma Aldrich® Summer Intern Program, Round Rock, TX, August 2012 

Analytical Challenges with MS Analysis of Bath Salts and Spice Cannabinoid Metabolites

Authors: Joshua Cooper, Ryan Carrell, Ning Chang, Yunming Ying, Greg Kirkovits, Derrell Johnson, Isil Dilek, Uma Sreenivasan
Presented at Society of Forensic Toxicologists (SOFT), Boston, MA, July 2012

±threo-Ritalinic acid-D10 Hydrochloride an internal standard for quantitation of Ritalinic acid by LCMSMS: Synthesis determination of isotopic distribution by qNMR and LCMS

Authors: Elizabeth B. Marek, Joshua Cooper, Huahua Jian, Uma Sreenivasan, Isil Dilek
Presented at Mass Spectrometry Application to the Clinical Lab (MSACL), San Diego, CA, January 2012

Evaluation of LCMSMS Deuterium Scrambling in Clinically Significant Small Molecules

Authors: Joshua Cooper, IsilDilek, UmaSreenivasan
Presented at Mass Spectrometry Application to the Clinical Lab (MSACL), San Diego, CA, January 2012

Improved GCMS Derivatization Techniques for Analysis of New Designer Drugs: Methylone, Ethylone, Butylone, Mephedrone, and Methedrone

Authors: Ryan Carrell, Isil Dilek, Ning Chang, Uma Sreenivasan, Yunming Ying, Greg Kirkovits
Presented at Society of Forensic Toxicologists (SOFT) / The International Association of Forensic Toxicologists (TIAFT), San Francisco, CA, September 2011

Certification of Reference Materials: Purity Analysis of Morphine-3β-D-Glucuronide by Quantitative NMR, Enzymatic Hydrolysis LC-MS/MS Assay, and Mass Balance Purity Factor

Authors: Huahua Jian, Martha Liu, Uma Sreenivasan and Isil Dilek
Presented at Society of Forensic Toxicologists (SOFT) / The International Association of Forensic Toxicologists (TIAFT), San Francisco, CA, September 2011

Analytical Reference Standards: Synthesis and Characterization of ±-threo-Ritalinic Acid-D10 Hydrochloride

Authors: Elizabeth B. Marek PhD, Huahua Jian PhD, Uma Sreenivasan PhD, Isil Dilek PhD
Presented at Society of Forensic Toxicologists (SOFT) / The International Association of Forensic Toxicologists (TIAFT), San Francisco, CA, September 2011

Everolimus-d4: An Internal Standard for Quantitation of Everolimus and Related Immunosuppressants by LCMS

Authors: Yunming Ying  PhD, Huahua Jian PhD, Isil Dilek PhD, Uma Sreenivasan PhD
Presented at Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock, TX 78665

Evaluation of LCMS/MS scrambling ratios for deuterium-labeled Vitamin D metabolites, steroids and other compounds of clinical significance

Authors: Joshua Cooper PhD, Huahua Jian PhD, Derrell Johnson, Isil Dilek PhD, and Uma Sreenivasan PhD
Presented at the American Association for Clinical Chemistry (AACC) Annual Meeting and Clinical Lab Expo, Atlanta, Ga, July 2011

Mitigation of Deuterium Scrambling in Stable-Labeled Internal Standards during LC-MS/MS Analysis

Authors: Joshua Cooper, Billy Molloy, Huahua Jian, Lisa Calton, Derrell Johnson, Isil Dilek, Uma Sreenivasan, Don Cooper
Presented at Mass Spectrometry Application to the Clinical Lab (MSACL), San Diego, CA, February 2011

High Quality, Certified Snap-N-Shoot Standards of Reb A & Stevia Impurities Ensure Accuracy & Consistency in Quantitative Applications

Authors: Mitzi Rettinger, Isil Dilek, PhD, Sandra Ybarra, Uma Sreenivasan, PhD, and Sherri Pogue
Presented at Association of Official Analytical Chemists (AOAC), Orlando, FL, September 2010

What Makes a Good Reference Standard

Authors: Mitzi Rettinger, Uma Sreenivasan, PhD, Isil Dilek, PhD, Sherri Pogue
Presented at Association of Official Analytical Chemists (AOAC), Orlando, FL, September 2010

Custom Certified Stock Solutions for Use in Manufacture of IVD Reagents or Controls

Authors: Mitzi Rettinger, Uma Sreenivasan, Isil Dilek, Sherri Pogue
Presented at American Association for Clinical Chemistry (Clinical Lab Expo) (AACC), Anaheim, CA, July 2010

Investigation of the Impurities in Dronabinol Samples by LCMS

Authors: Huahua Jian, Isil Dilek, Uma Sreenivasan, Kenan Yaser
Presented at Pittcon, Orlando, FL, March 2010

Measurement and Uncertainty of Residual Inorganic Content by Micro-ROI Analysis for Certification of Reference Materials

Authors: Ryan Carrell, HuaHua Jian, Kevin Gates, Isil Dilek, Uma Sreenivasan
Presented at Pittcon, Orlando, FL, March 2010

High Quality, Certified Snap-N-Shoot® Standards of Reb A and Stevia Impurities Ensure Accuracy and Consistency in Quantitative Applications

Authors: Mitzi Rettinger, Uma Sreenivassan, Isil Dilek
Presented at Stevia World Americas 2010, Atlanta, GA, February 2010

Certified Spiking Solutions® of Immunosuppressant Drugs

Authors: Uma Sreenivasan, Isil Dilek, Sandra Ybarra, Huahua Jian, Mitzi Rettinger
Presented at Mass Spectrometry Application to the Clinical Lab (MSACL), San Diego, February 2010

A Validated Chiral HPLC Method for Resolution of &Δ;8 and &Δ;9 – Tetrahydrocannabinol Enantiomers

Authors: Tamara Tarbox, Isil Dilek PhD, Uma Sreenivasan PhD, Kenan Yaser
Presented at EAS, November 2009

Validation of Residual Solvent Analysis in Neat Materials by GC/FID Headspace

Authors: Ning Chang PhD, Krystal Silva, Huahua Jian PhD, Isil Dilek PhD, Uma Sreenivasan PhD
Presented at EAS, November 2009

Synthesis of 13C6-glucuronic Acid Drug Metabolites

Authors: Alexander Wong PhD, Peech Reddy PhD, Martha Liu PhD
Presented at AAPS, November 2009

Brominated Oxymorphone Impurities: Regioselective Synthesis & Characterization of 1-Bromo- & 2-Bromoxymorphone

Authors: Elizabeth Marek PhD, Gregory Kirkovits PhD, Huahua Jian PhD, Uma Sreenivasan PhD
Presented at AAPS, November 2009

An Investigation of Norpropoxyphene Cyclization in Methanol

Authors: Huahua Jian PhD, Sandra Ybarra, Derrell Johnson MS, Isil Dilek PhD and Uma Sreenivasan PhD
Presented at SOFT, October 2009

Preparation and Uncertainty of Ethanol Standards

Authors: Ning Chang PhD, Isil Dilek PhD, Bryan Dockery, Kevin Gates, Huahua Jian PhD, Mitzi Rettinger, Krystal Silva, Uma Sreenivasan PhD
Presented at SOFT, October 2009

Certified Solution Standards for Clinical Applications

Authors: Isil Dilek PhD, Kevin Gates, Rebecca Johnson, Sherri Pogue, Mitzi Rettinger, Uma Sreenivasan PhD
Presented at TIAFT, August 2009

Preparation, Uncertainty & Certification of Ethanol Standards

Authors: Ning Change PhD, Isil Dilek PhD, Bryan Dockery, Kevin Gates, Huahua Jian PhD, Mitzi Rettinger, Krystal Silva, Uma Sreenivasan PhD
Presented at TIAFT, August 2009

Synthesis of CHMPA-D

Authors: Peech Reddy PhD, Huahua Jian PhD, Isil Dilek PhD, Ryan Carrell, Ning Chang PhD, Uma Sreenivasan PhD
Presented at NMEC, August 2009

Pharmaceutical Standards for Drinking Water Analysis

Authors: Derrell Johnson, Uma Sreenivasan PhD, Kevin Gates, Ning Chang PhD, Isil Dilek PhD, Huahua Jian PhD, Mitzi Rettinger
Presented at NMEC, August 2009

The Uncertainty of Reference Standards - A Guide to Understanding Factors Impacting Uncertainty, Uncertainty Calculations and Vendor Certifications

Authors: Ning Chang PhD, Isil Dilek PhD, Kevin Gates, Huahua Jian PhD, Sherri Pogue, Uma Sreenivasan PhD
Presented at SAT, May 2009

Certified Solution Standards for Therapeutic Drug Monitoring Applications

Authors: Isil Dilek PhD, Kevin Gates, Rebecca Johnson, Sherri Pogue, Mitzi Rettinger, Uma Sreenivasan PhD
Presented at SAT, May 2009
Presented at MATT, April 2009