2C-B-FLY (1) and Bromo-DragonFLY (2), are recreational designer drugs based on phenethylamines such as 2C-B (3). 2C-B-FLY and Bromo-DragonFLY exhibit potent and long lasting psychedelic and hallucinogenic properties.^1-3 Compounds 1 and 2 were synthesized from literature methods,^1-3 and formulated into certified reference materials (CRM’s) for forensic and clinical toxicology testing by LC/ MS and/or GC/MS.
 

Stable labeled internal standards (IS’s) are required for accurate quantitation by mass spectrometry (MS). Labeling can be accomplished through the incorporation of deuterium, carbon-13 and/or nitrogen-15. The design and synthesis of the desired labeled materials will be presented.

 

References

 

1. J. Med. Chem. 1196, 39, 2953-2961
2. J. Med. Chem. 2001, 44, 1003-1010

3. J. Med. Chem. 1998, 41, 5148-5149