A study recently published in the journal
PlosOne has demonstrated that
combination morphine and carbamazepine therapy is more effective than morphine
monotherapy in managing neuropathic pain. According to the study’s authors, over-stimulation
of inflammatory nerve cells by a morphine metabolite can dampen the analgesic
effects of morphine and even cause pain in neuropathic pain models (
Carbamazepine
Potentiates the Effectiveness of Morphine in a Rodent Model of Neuropathic Pain).
Researchers showed that carbamazepine, an antiepileptic
drug, can reduce inflammatory activity in nerve cells that are thought to be
over-stimulated by morphine-3-glucuronide, an active metabolite of morphine. Using
a rodent model, researchers conducted in-vitro and in-vivo experiments to
assess the cellular effects of combination carbamazepine and morphine therapy.
In-vitro experiments showed that carbamazepine can prevent over-stimulation of
the inflammatory response in nerve cells caused by morphine-3-glucuronide. In
the in-vivo experiment, combination morphine and carbamazepine therapy
alleviated pain 28 days after injury, whereas morphine monotherapy required
increasing the dosage over the same time period.
The authors noted that additional studies are underway to
investigate the effects of adding carbamazepine or related compounds to
morphine neuropathic pain therapies. Currently,
researchers at the Indiana University Melvine and Bren Simon Cancer Center are
testing the combination of morphine and oxcarbazepine, an antiepileptic similar
in structure to carbamazepine, among patients in a small clinical trial.
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opiate and synthetic analgesic Certified Spiking Solutions®: