CerilliantLog In | Recently Purchased | Favorites | My COAs | Cart (0)Cerilliant ISO

Brominated Oxymorphone Impurities: Regioselective Synthesis & Characterization of 1-Bromo- & 2-Bromoxymorphone

Authors: Elizabeth Marek PhD, Gregory Kirkovits PhD, Huahua Jian PhD, Uma Sreenivasan PhD
Presented at AAPS, November 2009

The use of synthetic opiate impurities as reference materials has become vital to the pharmaceutical industry. To this end, brominated Oxymorphone impurities 1-bromooxymorphone (1) and 2-bromooxymorphone (2) were synthesized using desirable short, direct, and Regioselective methods. Using a combination of 1H, 13C and 2-D NMR spectra, unequivocal evidence for the electrophilic aromatic substitution of brominates at the 1- and 2-positions of the aromatic ring of Oxymorphone has been demonstrated.

view poster

return to papers and poster presentations

© 2024 Cerilliant Corporation | 811 Paloma Drive, Suite A | Round Rock, Texas 78665
MilliporeSigma is a business of Merck KGaA, Darmstadt, Germany
Products | Sitemap | Privacy Policy | EHS Policy | Terms & Conditions | Contact