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Variables that Impact Immunosuppressant LC-MS/MS Analysis

Authors: Josh Cooper, Beth Marek, Isil Dilek, and Uma Sreenivasan
Presented at 61st American Society for Mass Spectrometry (ASMS) Conference, Minneapolis, MN, June 2013

Clinical analysis of immunosuppressants by LC-MS/MS can be challenging because patient samples are in whole blood and require extensive sample preparation. In addition, the large size of these molecules makes obtaining reasonable peak shape chromatographically challenging. LC-MS/MS immunosuppressant method development revealed extensive sample to sample variability for everolimus, sirolimus, and tacrolimus. Several parameters such as sample preparation, MS interference, and surface interaction between the compounds and the glass sample containers were investigated to determine the cause of the observed analytical variability

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