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Certification of Reference Materials: Purity Analysis of Morphine-3β-D-Glucuronide by Quantitative NMR, Enzymatic Hydrolysis LC-MS/MS Assay, and Mass Balance Purity Factor

Authors: Huahua Jian, Martha Liu, Uma Sreenivasan and Isil Dilek
Presented at Society of Forensic Toxicologists (SOFT) / The International Association of Forensic Toxicologists (TIAFT), San Francisco, CA, September 2011

Many drugs are rapidly and extensively metabolized to their glucuronide conjugates for excretion. Detection and quantitation of drug glucuronides is an essential part of forensic and toxicologic analyses. Test results have potential social, legal and clinical significance. The purity value assigned to these reference materials therefore has a critical impact on the quality of analytical results. As a class, glucuronides tend to be polar, hygroscopic, difficult to manufacture and handle, and they can be challenging to analyze and certify. Method of certification is critical and depends on the material to be tested.

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