Butyryl fentanyl is a designer drug and fentanyl analog that has been associated with numerous opioid overdose deaths. In May 2016, the U.S Drug Enforcement Administration (DEA) classified butyryl fentanyl as a schedule I controlled substance. A certified Snap-N-Shoot^® solution suitable for quantification of butyryl fentanyl by LC/MS or GC/MS testing methods in clinical toxicology, urine drug testing, prescription monitoring, or forensic analysis applications. This Certified Spiking Solution® is supplied in a convenient US DEA-exempt solution format.