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Challenges in the Development of Certified Vitamin Reference Solutions

Authors: Beth Marek, Derrell Johnson, Isil Dilek, Mitzi Rettinger
Presented at Association of Official Analytical Chemists (AOAC), Las Vegas, NV, October 2012

Abstract
Vitamins are essential for general health and well-being. From patient samples in clinical laboratories to manufacturers of dietary supplements and fortified foods, use of Certified Reference Materials (CRM) for vitamin testing applications is critical to ensure accurate results. Effective reference materials must be quantitative, accurate, consistent, and stable. Certified solution reference standards with suitable diluents at appropriate concentrations and in sealed ampoules under inert conditions can offer significant advantages over neat reference materials in terms of accuracy, consistency, and stability.

Factors such as chromatographic purity, hygroscopicity, solubility, and stability of the neat material must be determined and assessed prior to preparation of the reference standard solution. Handling and preparation of vitamin reference solutions present significant challenges due to their sensitivity to air, light, and solution pH. This poster will discuss the unique challenges in development of certified solution standards of certain vitamins, including vitamins A , B, D and E


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