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Cerilliant Introduces Snap-N-Spike® Stable-Labeled Internal Standards of Antifungal Agents

ST.LOUIS– June 9, 2015– Sigma-Aldrich Corporation (NASDAQ:SIAL) announced today that the Cerilliant® brand within its Applied Diagnostics and Testing business unit has introduced five new stable-labeled internal standards of the antifungal agents fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole at 1.0 mg/mL concentrations.
 
Antifungal agents offer critically ill or immunocompromised patients multiple treatment options against invasive fungal infections. The use of antifungals can, however, impact drug metabolism and drug interactions due to their ability to act as a substrate or inhibitor of cytochrome P450 (CYP) metabolic enzymes2, 3 thus presenting several clinical challenges including interactions with co-administered drugs, concentration-dependent toxicity, and variations in drug absorption and metabolism. Therapeutic drug monitoring (TDM) by LC-MS/MS is considered for antifungal drugs to avoid such adverse clinical outcomes and to ensure effectiveness of the drug regimen.1, 2
 
Cerilliant’s solution certified reference materials offer clinical and diagnostic testing labs, hospitals, and bioanalytical/PKDM labs a full selection of internal standards for quantitation of the most common antifungal drugs in serum or plasma by mass spectrometry-based analytical methods. The deuterium or 13C substitutions of each internal standard were carefully chosen to conserve a minimum [M+3] separation from the unlabeled drug in the major ion fragments used in LC-MS/MS antifungal TDM applications and metabolism studies.
 
These new internal standards complement Cerilliant’s diverse catalog offering of triazole, imidazole, and other azole antifungal Certified Spiking Solutions®. Coming soon, Cerilliant will also introduce stable-labeled internal standards for the antifungal metronidazole and active metabolite hydroxyitraconazole. Cerilliant certified reference solutions are manufactured and certified to the highest industry standards including ISO Guide 34, ISO/IEC 17025, and ISO 13485 and are compliant with ISO 15194.


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